Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular dockingArticle Published on 2023-04-012023-06-12 Journal: Biotechnology letters [Category] B형 간염, [키워드] hepatitis B molecular docking network pharmacology Traditional Chinese medicine Zhizi-Bopi decoction. [DOI] 10.1007/s10529-023-03359-x PMC 바로가기
Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathwayArticle Published on 2023-01-302022-11-15 Journal: Journal of ethnopharmacology [Category] 유전자 메커니즘, 진단, [키워드] Activation acute lung injury ALI model alleviate Analysis analysis attenuate Baidu caused Cell cellular China component Component analysis components Compound COVID-19 COVID-19 patients demonstrated experiment experimental validation Formula in vivo increases in indicated Inflammation ingredient inhibited inhibiting Kyoto lung Lung injury material mechanism of action Mild molecular mechanism network network pharmacology NF-κB pathway NF-κB signaling NF-κB signaling pathway Obstructive Ontology p-NF-κB p65 pathway pharmacological predicted proinflammatory Proteins reduced syndrome target treat Treatment Xuanfei baidu formula. [DOI] 10.1016/j.jep.2022.115833 PMC 바로가기
The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathwayArticle Published on 2023-01-102023-06-24 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, [키워드] Antiviral mechanism influenza A (H1N1) virus network pharmacology TLR3 signaling pathway Trollius chinensis Bunge. [DOI] 10.1016/j.jep.2022.115743 PMC 바로가기
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Clinical features and effectiveness of Chinese medicine in patients with COVID-19 from overseas: A retrospective study in Xiamen, ChinaArticle Published on 2022-10-242023-07-10 Journal: Frontiers in Public Health [Category] COVID19(2023년), [키워드] bioinformatics Chinese medicine COVID-19 network pharmacology Retrospective study. SARS-CoV-2 [DOI] 10.3389/fpubh.2022.1038017 PMC 바로가기
Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacologyArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral drugs antiviral immunity APCS approach Ayurveda binding affinity cardiovascular complications Comorbidities Comorbidity COVID-19 creating develop Diabetes Mellitus disorders effective highlighting Host hypertension immunomodulators investigated mechanism molecular docking network network pharmacology novel coronavirus disease Protein target public health regulate Regulatory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2. synergistic therapy Traditional virus Wuhan, China [DOI] 10.1007/s11030-021-10352-x PMC 바로가기
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
Artificial Neural Network-Based Study Predicts GS-441524 as a Potential Inhibitor of SARS-CoV-2 Activator Protein Furin: a Polypharmacology ApproachArticle Published on 2022-10-012022-11-15 Journal: Applied biochemistry and biotechnology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activator ANN Antiviral antiviral drug antivirals artificial Bacterial Bacterial infection Cancer caused Compound COVID-19 diabetes DNA drug Drug repurposing ENhance FCGR1A FDA furin furin cleavage site Grazoprevir GS-441524 help human protein inhibit inhibiting inhibitor inhibitors LB-VS LDLR mammalian MK-5172 network pharmacology Neural Neurological disorders pandemic Patient PCK1 PNP polybasic Polypharmacology Potential researcher SARS-CoV-2 SB-VS searched SOM. substrate target the spike protein TLR7 turn Virtual screening virus virus [DOI] 10.1007/s12010-022-03928-2 PMC 바로가기
Exploring the role of Xingren on COVID-19 based on network pharmacology and molecular dockingArticle Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] 유전자 메커니즘, [키워드] Almond Analysis Anxiety Asthma binding energy blood lipids blood pressure Brain China Chinese cough COVID-19 disease disorder docking drugs enrichment analysis function human immunity IL-17 ingredient intervene involved KEGG pathway mechanism metabolic process molecular molecular docking network network pharmacology Network pharmacology. nine outbreak potential mechanism provide PTGS2 reactive oxygen specy Regulation Research signaling pathway target Treatment variety were used Xingren [DOI] 10.1111/jfbc.14363 PMC 바로가기
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기